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SGT-67 is a type of designer medication known as synthetic cannabinoids.
SGT-67 (5F-CUMYL-PICA) is a 5F-APICA counterpart having an N-cumyl group in place of the N-adamantyl group. 5F-CUMYL-PICA is thought to act as a cannabinoid receptor agonist. This item is designed for forensic and research purposes.
In the family of synthetic cannabinoids, Sgt-67 is a new research chemical. 1-(5-fluoropentyl)-n-(2-phenylpropan-2-yl)-1h-indole-3-carboxamide is the chemical’s IUPAC name.
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One study on SGT-67 used rat and human liver microsomes and hepatocytes to evaluate the metabolism and clearance of the research chemical, which was compared to urine sampling and in vivo rat plasma.
Hypothermia was also investigated; treatment with microsomes revealed rapid metabolic clearance; however, metabolism in vivo took longer, allowing detection in rat plasma. With 28 metabolites identified, the research chemical did exhibit hypothermic effects.
SGT-67 (5F-CUMYL-PICA) Details
Molecular formula: C23H27FN2O
Molecular weight: 366.471
Chemical name: N- (2-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide
CAS number: 1400742-18-8
Appearance: White powder
Purity: (to be confirmed by GCMS)
Pharmacology
Pharmacology has gotten very little attention so far. It is, however, centered on a synthetic cannabinoid from the indazole family. The main difference between it and its closest relative is that the N-adamantyl group has been replaced with an N-cumyl gathering in the formula. It should have 5F-CUMYL selectivity for the CBI receptor while also anguishing the CB2 receptor.
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In recent years, there’s been an increase in the number of media reports on users of synthetic cannabinoids. Commonly referred to by names such as ‘Spice’ or ‘K2’, the most recent reported case involved five UK students being hospitalised after use. But what are the chemicals present in ‘spice’ and similar drugs, and what are the chemical compounds in cannabis that they aim to mimic? That’s what this graphic and post attempt to answer.
Let’s start with cannabis. Cannabis contains a large number of compounds known as ‘cannabinoids’. These are produced naturally by the plant, and the most important is tetrahydrocannabinol, or THC. This is the major compound in cannabis responsible for the drug’s effects. The cannabinoids in cannabis target the cannabinoid receptors; these come in two varieties, CB1 and CB2 receptors. CB1 receptors are found primarily in the brain, and it’s the interaction of cannabinoids with these receptors that is responsible for psychological effects. The CB2 receptors are found mainly in the immune system and are partly responsible for the anti-inflammatory and potential medicinal benefits of cannabis (though in some cases, these are also due to interaction with CB1 receptors).
